Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase α-primase

The wild-type form of p53 contains an intrinsic 3′–5′-exonuclease activity. As p53 forms a complex with DNA polymerase α-primase (pol-prim) in vivo this finding suggests that p53 might cooperate with pol-prim to stabilize the genetic information of living cells. To test this hypothesis, exonuclease-...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Melle, Christian, Nasheuer, Heinz-Peter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11917009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.7.1493
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