Prenatal diagnosis of myotonic dystrophy using closely linked flanking markers.

We report on two cases of prenatal diagnosis of myotonic dystrophy (DM), using flanking markers APOC2 or CKMM on the proximal side and D19S51 on the distal side. By double digestion (TaqI and NcoI) of PCR amplified CKMM, the informativeness was increased from a PIC value of 0.57 to 0.69. Altogether,...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lavedan, C, Hofmann, H, Shelbourne, P, Duros, C, Savoy, D, Johnson, K, Junien, C
Format: Artigo
Langue:Inglês
Publié: 1991
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1016774/
https://ncbi.nlm.nih.gov/pubmed/2002492
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