Tripeptidyl Peptidase II Promotes Maturation of Caspase-1 in Shigella flexneri-Induced Macrophage Apoptosis

The invasive enteropathogenic bacterium Shigella flexneri activates apoptosis in macrophages. Shigella-induced apoptosis requires caspase-1. We demonstrate here that tripeptidyl peptidase II (TPPII), a cytoplasmic, high-molecular-weight protease, participates in the apoptotic pathway triggered by Sh...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Hilbi, Hubert, Puro, Robyn J., Zychlinsky, Arturo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC101498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10992446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.10.5502-5508.2000
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