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Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers

BACKGROUND: Previously, we have demonstrated a marked inhibition of codeine glucuronidation by diclofenac in human liver tissue homogenate. We therefore aimed to investigate whether diclofenac inhibits glucuronidation of codeine also in vivo in healthy volunteers. METHODS: In a randomised, placebo-c...

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Hlavní autoři: Ammon, Susanne, Marx, Claudia, Behrens, Christoph, Hofmann, Ute, Mürdter, Thomas, Griese, Ernst-Ulrich, Mikus, Gerd
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC101395/
https://ncbi.nlm.nih.gov/pubmed/11943073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6904-2-2
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