Chemical incorporation of 1-methyladenosine into oligonucleotides

The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides.

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Main Authors: Mikhailov, Sergey N., Rozenski, Jef, Efimtseva, Ekaterina V., Busson, Roger, Van Aerschot, Arthur, Herdewijn, Piet
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2002
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC101250/
https://ncbi.nlm.nih.gov/pubmed/11861902
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