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Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX

AFX belongs to a subfamily of Forkhead transcription factors that are phosphorylated by protein kinase B (PKB), also known as Akt. Phosphorylation inhibits the transcriptional activity of AFX and changes the steady-state localization of the protein from the nucleus to the cytoplasm. Our goal was thr...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Brownawell, Amy M., Kops, Geert J. P. L., Macara, Ian G., Burgering, Boudewijn M. T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2001
Schlagworte:
Nucleocytoplasmic Communication
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC100275/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11313479/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.10.3534-3546.2001
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