Enhanced Gamma Interferon Production through Activation of Vα14(+) Natural Killer T Cells by α-Galactosylceramide in Interleukin-18-Deficient Mice with Systemic Cryptococcosis

We showed recently that activation of Vα14(+) natural killer T cells (NKT cells) by α-galactosylceramide (α-GalCer) resulted in increased gamma interferon (IFN-γ) production and host resistance to intravenous infection with Cryptococcus neoformans. In other studies, interleukin-18 (IL-18) activated...

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Dettagli Bibliografici
Autori principali: Kawakami, Kazuyoshi, Kinjo, Yuki, Yara, Satomi, Uezu, Kaori, Koguchi, Yoshinobu, Tohyama, Masaki, Azuma, Masato, Takeda, Kiyoshi, Akira, Shizuo, Saito, Atsushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Host Response and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC100038/
https://ncbi.nlm.nih.gov/pubmed/11598033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.11.6643-6650.2001
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