The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation

The newly discovered p73 gene encodes a nuclear protein that has high homology with p53. Furthermore, ectopic expression of p73 in p53(+/+) and p53(−/−) cancer cells recapitulates some of the biological activities of p53 such as growth arrest, apoptosis, and differentiation. p73(−/−)-deficient mice...

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Bibliographische Detailangaben
Hauptverfasser: Fontemaggi, Giulia, Gurtner, Aymone, Strano, Sabrina, Higashi, Yujiro, Sacchi, Ada, Piaggio, Giulia, Blandino, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC100009/
https://ncbi.nlm.nih.gov/pubmed/11713281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8461-8470.2001
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