Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been implicated in several types of cancers. In recent years, tyrosine kinase inhibitors (TKIs) have been developed to interfere wit...

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Bibliographic Details
Main Authors: Nagaraju Anreddy, Pranav Gupta, Rishil J. Kathawala, Atish Patel, John N. D. Wurpel, Zhe-Sheng Chen
Format: Artigo
Language:Inglês
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
tyrosine kinase inhibitors
ABC transporters
chemotherapy
modulators
multidrug resistance
Online Access:http://www.mdpi.com/1420-3049/19/9/13848
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