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Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector

Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway for regulating energy balance—is brain-derived neurotr...

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Detalhes bibliográficos
Main Authors: Jason J. Siu, Nicholas J. Queen, Xianglan Liu, Wei Huang, Travis McMurphy, Lei Cao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-12-01
Colecção:Molecular Therapy: Methods & Clinical Development
Assuntos:
AAV
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2329050117301043
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