Genetic Manipulation of Brown Fat Via Oral Administration of an Engineered Recombinant Adeno-associated Viral Serotype Vector

Recombinant adeno-associated virus (rAAV) vectors are attractive vehicles for gene therapy. Gene delivery to the adipose tissue using naturally occurring AAV serotypes is less successful compared to liver and muscle. Here, we demonstrate that oral administration of an engineered serotype Rec2 led to...

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Vydáno v:Mol Ther
Hlavní autoři: Huang, Wei, McMurphy, Travis, Liu, Xianglan, Wang, Chuansong, Cao, Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923319/
https://ncbi.nlm.nih.gov/pubmed/26857843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.34
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