Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer

Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC). Patients diagnosed with EGFR-mutant NSCLC have good initial clinical response to EGFR tyrosine kinase inhibitors (EGFR T...

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Main Authors: Tatiana Shaurova, Letian Zhang, David W. Goodrich, Pamela A. Hershberger
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-03-01
Serier:Frontiers in Genetics
Fag:
EGFR mutant lung cancer
EGFR tyrosine kinase inhibitors
acquired resistance
lineage plasticity
epithelial-mesenchymal transition
neuroendocrine transformation
Online adgang:https://www.frontiersin.org/article/10.3389/fgene.2020.00281/full
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