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Clinical-grade generation of active NK cells from cord blood hematopoietic progenitor cells for immunotherapy using a closed-system culture process.

Natural killer (NK) cell-based adoptive immunotherapy is a promising treatment approach for many cancers. However, development of protocols that provide large numbers of functional NK cells produced under GMP conditions are required to facilitate clinical studies. In this study, we translated our cy...

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Autores principales: Jan Spanholtz, Frank Preijers, Marleen Tordoir, Carel Trilsbeek, Jos Paardekooper, Theo de Witte, Nicolaas Schaap, Harry Dolstra
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2011-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3116834?pdf=render
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