Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV.

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that emp...

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Hlavní autoři: Simone Conti, Victor Ovchinnikov, Jonathan G Faris, Arup K Chakraborty, Martin Karplus, Kayla G Sprenger
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2022-04-01
Edice:PLoS Computational Biology
On-line přístup:https://doi.org/10.1371/journal.pcbi.1009391
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