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Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV.
The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that emp...
Tallennettuna:
Päätekijät: | , , , , , |
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Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
Public Library of Science (PLoS)
2022-04-01
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Sarja: | PLoS Computational Biology |
Linkit: | https://doi.org/10.1371/journal.pcbi.1009391 |
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