Up-regulation of selenoprotein P and HIP/PAP mRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203

Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) and is a risk factor for insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and insulin resistance remain elusive. We exposed human hepatocytes...

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Bibliografske podrobnosti
Main Authors: Tomoko Uchiyama, Hiroyo Ota, Asako Itaya-Hironaka, Ryogo Shobatake, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Hiroshi Kimura, Maiko Takeda, Chiho Ohbayashi, Shin Takasawa
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017-09-01
Serija:Biochemistry and Biophysics Reports
Teme:
Hepatokine
HIP/PAP
Intermittent hypoxia
miR-203
REG family gene
SELENOP
Online dostop:http://www.sciencedirect.com/science/article/pii/S2405580817301139
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