Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.

To investigate the underlying causes of chemoresistance in malignant pleural mesothelioma, we have studied mesothelioma cell lines as 3D spheroids, which acquire increased chemoresistance compared to 2D monolayers. We asked whether the gene expression of 3D spheroids would reveal mechanisms of resis...

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Huvudupphovsmän: Dario Barbone, Loes Van Dam, Carlo Follo, Puthen V Jithesh, Shu-Dong Zhang, William G Richards, Raphael Bueno, Dean A Fennell, V Courtney Broaddus
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science (PLoS) 2016-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC4794185?pdf=render
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