Which pathways trigger the role of complement in ischaemia/reperfusion injury?

Investigations into the role of complement in ischaemia/reperfusion injury have identified common effector mechanisms that depend on the production of C5a and C5b-9 through the cleavage of C3. These studies have also defined an important role for C3 synthesised within ischaemic kidney. Less clear ho...

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Autori principali: Conrad Anthony Farrar, Elham eAsgari, Wilhelm J Schwaeble, Steven eSacks
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2012-11-01
Serie:Frontiers in Immunology
Soggetti:
Kidney
Reperfusion
ischaemia
complement
MBL
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00341/full
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