Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years. Pulmonary hypertension (PH) is a frequently fatal complication of CPFE. Despite this dismal prognosis, no curative...

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Main Authors: Scott D. Collum, Jose G. Molina, Ankit Hanmandlu, Weizhen Bi, Mesias Pedroza, Tinne C. J. Mertens, Nancy Wareing, Wang Wei, Cory Wilson, Wenchao Sun, Jayakumar Rajadas, Paul L. Bollyky, Kemly M. Philip, Dewei Ren, Rajarajan A. Thandavarayan, Brian A. Bruckner, Yang Xia, Michael R. Blackburn, Harry Karmouty-Quintana
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2019-05-01
Series:Disease Models & Mechanisms
Assuntos:
Group III PH
Hyaluronan
Lung fibrosis
Pulmonary hypertension
Adenosine
Airspace enlargement
Macrophages
Hyaluronan synthases
Acceso en liña:http://dmm.biologists.org/content/12/5/dmm038711
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