Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

This study aimed at improving the targeting and cytotoxic effect of ellagic acid (EA) on colon cancer cells. EA was encapsulated in chitosan (CHIT) polymers then coated by eudragit S100 (ES100) microparticles. The release of EA double-coated microparticles (MPs) was tested at simulative pH values. M...

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Main Authors: Nabil A. Alhakamy, Osama A. A. Ahmed, Mallesh Kurakula, Giuseppe Caruso, Filippo Caraci, Hani Z. Asfour, Anas Alfarsi, Basma G. Eid, Amir I. Mohamed, Nabil K. Alruwaili, Wesam H. Abdulaal, Usama A. Fahmy, Hani A. Alhadrami, Basmah M. Eldakhakhny, Ashraf B. Abdel-Naim
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Pharmaceutics
Assuntos:
chitosan
ellagic acid
drug release
muco-adhesion
colon targeting
Acesso em linha:https://www.mdpi.com/1999-4923/12/7/652
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