Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

DNA damage causally contributes to aging and age-related diseases. Mutations in nucleotide excision repair (NER) genes cause highly complex congenital syndromes characterized by growth retardation, cancer susceptibility, and accelerated aging in humans. Orthologous mutations in Caenorhabditis elegan...

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Detalhes bibliográficos
Main Authors: Diletta Edifizi, Hendrik Nolte, Vipin Babu, Laia Castells-Roca, Michael M. Mueller, Susanne Brodesser, Marcus Krüger, Björn Schumacher
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-08-01
Colecção:Cell Reports
Assuntos:
DNA damage response
nucleotide excision repair
DNA repair
aging
Caenorhabditis elegans
proteomics
lipidomics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221112471731135X
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