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Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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Detaylı Bibliyografya
Asıl Yazarlar: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2019-11-01
Seri Bilgileri:BMC Biology
Konular:
Online Erişim:http://link.springer.com/article/10.1186/s12915-019-0711-z
Etiketler: Etiketle
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