Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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Bibliographic Details
Main Authors: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Format: Artigo
Language:Inglês
Published: BMC 2019-11-01
Series:BMC Biology
Subjects:
CRISPR/Cas9
Genome editing
Epigenome editing
DNA methylation
HPRT1
Gene silencing
Online Access:http://link.springer.com/article/10.1186/s12915-019-0711-z
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