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Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2019-11-01
Saila:BMC Biology
Gaiak:
Sarrera elektronikoa:http://link.springer.com/article/10.1186/s12915-019-0711-z
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