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Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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主要な著者: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2019-11-01
シリーズ:BMC Biology
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オンライン・アクセス:http://link.springer.com/article/10.1186/s12915-019-0711-z
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