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Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

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Bibliografische gegevens
Hoofdauteurs: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2019-11-01
Reeks:BMC Biology
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Online toegang:http://link.springer.com/article/10.1186/s12915-019-0711-z
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