Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-...

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Hlavní autoři: Jonathan E. Schoenhals, Taylor R. Cushman, Hampartsoum B. Barsoumian, Ailin Li, Alexandra P. Cadena, Sharareh Niknam, Ahmed I. Younes, Mauricio da Silva Caetano, Maria Angelica Cortez, James W. Welsh
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-09-01
Edice:Frontiers in Immunology
Témata:
PD1 resistance
radiotherapy
immunotherapy
GITR
cancer
On-line přístup:https://www.frontiersin.org/article/10.3389/fimmu.2018.02170/full
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