A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane trafficking controls Aβ levels is unclear. Here, we perfo...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, AESG, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2013-12-01
Serie:Cell Reports
Länkar:http://www.sciencedirect.com/science/article/pii/S2211124713007353
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk