A Paired RNAi and RabGAP Overexpression Screen Identifies Rab11 as a Regulator of β-Amyloid Production

Alzheimer’s disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides, which are generated from amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are membrane associated, but whether membrane trafficking controls Aβ levels is unclear. Here, we perfo...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Vinod Udayar, Virginie Buggia-Prévot, Rita L. Guerreiro, Gabriele Siegel, Naresh Rambabu, Amanda L. Soohoo, Moorthi Ponnusamy, Barbara Siegenthaler, Jitin Bali, AESG, Mikael Simons, Jonas Ries, Manojkumar A. Puthenveedu, John Hardy, Gopal Thinakaran, Lawrence Rajendran
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2013-12-01
Serija:Cell Reports
Online dostop:http://www.sciencedirect.com/science/article/pii/S2211124713007353
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki