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IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging
CD4+Foxp3+Tregs maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3+ cells altered their function and resulted in increased fungal burden and immunopathology...
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Hoofdauteurs: | , , , , , , , |
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Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
Frontiers Media S.A.
2020-11-01
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Reeks: | Frontiers in Immunology |
Onderwerpen: | |
Online toegang: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.595936/full |
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