IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging

CD4+Foxp3+Tregs maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3+ cells altered their function and resulted in increased fungal burden and immunopathology...

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Detalhes bibliográficos
Main Authors: Natarajan Bhaskaran, Fady Faddoul, Andre Paes da Silva, Sangeetha Jayaraman, Elizabeth Schneider, Prerna Mamileti, Aaron Weinberg, Pushpa Pandiyan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-11-01
Colecção:Frontiers in Immunology
Assuntos:
Treg
Foxp3
Treg17
IL-1β
Candida
fungal infection
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2020.595936/full
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