IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A(+)Foxp3(+) Cells During Mucosal Infection and Is Dysregulated With Aging

CD4(+)Foxp3(+)T(regs) maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3(+) cells altered their function and resulted in increased fungal burden and immunop...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Immunol
Päätekijät: Bhaskaran, Natarajan, Faddoul, Fady, Paes da Silva, Andre, Jayaraman, Sangeetha, Schneider, Elizabeth, Mamileti, Prerna, Weinberg, Aaron, Pandiyan, Pushpa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2020
Aiheet:
Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677307/
https://ncbi.nlm.nih.gov/pubmed/33240286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.595936
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