Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands

Interleukin-1β (IL-1β) binds to the IL-1 receptor (IL-1R) and is a key cytokine mediator of inflammasome activation. IL-1β signaling leads to parturition in preterm birth (PTB) and contributes to the retinal vaso-obliteration characteristic of oxygen-induced retinopathy (OIR) of premature infants. T...

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Main Authors: Azade Geranurimi, Colin W. H. Cheng, Christiane Quiniou, Tang Zhu, Xin Hou, José Carlos Rivera, Daniel J. St-Cyr, Kim Beauregard, Vadim Bernard-Gauthier, Sylvain Chemtob, William D. Lubell
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-02-01
Colecção:Frontiers in Chemistry
Assuntos:
β-hydroxy-α-amino-γ-lactam (Hgl)
interleukin-1 receptor antagonist
101.10 (rytvela)
β-turn
Freidinger lactams
solid-phase peptide synthesis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fchem.2019.00023/full
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