A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway

The prostaglandin F2α (PGF2α) receptor (FP) is a key regulator of parturition and a target for pharmacological management of preterm labor. However, an incomplete understanding of signaling pathways regulating myometrial contraction hinders the development of improved therapeutics. Here we used a pe...

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Hlavní autoři: Goupil, Eugénie, Tassy, Danaë, Bourguet, Carine, Quiniou, Christiane, Wisehart, Veronica, Pétrin, Darlaine, Le Gouill, Christian, Devost, Dominic, Zingg, Hans H., Bouvier, Michel, Saragovi, Horacio Uri, Chemtob, Sylvain, Lubell, William D., Claing, Audrey, Hébert, Terence E., Laporte, Stéphane A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919126/
https://ncbi.nlm.nih.gov/pubmed/20551320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115196
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