Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C) in East Asians

Thiopurines are clinically useful in the management of diverse immunological and malignant conditions. Nevertheless, these purine analogues can cause lethal myelosuppression, which may be prevented by prospective testing for variants in the thiopurine S-methyltransferase (TPMT) and, in East Asians,...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Chi-Chun Ho, Wai-Ying Fong, Yuen-Hon Lee, Wing-Tat Poon
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2017-10-01
श्रृंखला:Genes
विषय:
Asian
NUDT15
TPMT*3C
low-cost
genotyping
amplification-refractory mutation system
pharmacogenetic
rs1142345
rs116855232
sequencing
thiopurine intolerance
ऑनलाइन पहुंच:https://www.mdpi.com/2073-4425/8/10/285
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