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Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells

Background: The understanding of the regulation of glucagon secretion by pancreatic islet α-cells remains elusive. We aimed to develop an in vitro model for investigating the function of human α-cells under direct influence of glucose and other potential regulators. Methods: Highly purified human α-...

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Bibliographic Details
Main Authors: Wei Liu, Tatsuya Kin, Siuhong Ho, Craig Dorrell, Sean R. Campbell, Ping Luo, Xiaojuan Chen
Format: Artigo
Language:Inglês
Published: Elsevier 2019-12-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419307674
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