Preparation of Sterically Demanding 2,2-Disubstituted-2-Hydroxy Acids by Enzymatic Hydrolysis

Preparation of optically-pure derivatives of 2-hydroxy-2-(3-hydroxyphenyl)-2-phenylacetic acid of general structure 2 was accomplished by enzymatic hydrolysis of the correspondent esters. A screening with commercial hydrolases using the methyl ester of 2-hydroxy-2-(3-hydroxyphenyl)-2-phenylacetic ac...

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Detalhes bibliográficos
Main Authors: Andrea Pinto, Immacolata Serra, Diego Romano, Martina Letizia Contente, Francesco Molinari, Fabio Rancati, Roberta Mazzucato, Laura Carzaniga
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-01-01
Colecção:Catalysts
Assuntos:
esterase
stereoselective
ester hydrolysis
antimuscarinic agents
pig liver esterase (PLE)
Acesso em linha:https://www.mdpi.com/2073-4344/9/2/113
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