Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells

Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent cells, while HCs communicate the intra and extracellular compartments. In this way, bo...

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Bibliographic Details
Main Authors: Vania A Figueroa, Mauricio A Retamal, Luis A Cea, Jose D Salas, Aníbal A Vargas, Christian A Verdugo, Oscar eJara, Agustin D Martínez, Juan C Sáez
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Aminoglycosides
intracellular calcium
membrane current
connexons
Cx26
dye uptake
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00265/full
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