Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells

Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent cells, while HCs communicate the intra and extracellular compartments. In this way, bo...

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Detalhes bibliográficos
Main Authors: Figueroa, Vania A., Retamal, Mauricio A., Cea, Luis A., Salas, José D., Vargas, Aníbal A., Verdugo, Christian A., Jara, Oscar, Martínez, Agustín D., Sáez, Juan C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154469/
https://ncbi.nlm.nih.gov/pubmed/25237294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00265
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