Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)

Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted therapies in cancers has led to the development of highly aggressive carcinoma, including neuroendocrine prostate cancer (NEPC). Although metabolic repr...

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Main Authors: Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, Yanting Shen, Yi Sun, Lingfan Xu, Nan Song, Yue Wang, Ming Zhan, Xu Gao, Zhong Wang
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2022-05-01
Serija:Molecular Metabolism
Teme:
Neuroendocrine prostate cancer
Castration-resistant prostate cancer
Mitochondrial pyruvate carrier
Metabolic reprogramming
Online dostop:http://www.sciencedirect.com/science/article/pii/S2212877822000357
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