Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)

Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted therapies in cancers has led to the development of highly aggressive carcinoma, including neuroendocrine prostate cancer (NEPC). Although metabolic repr...

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Detalhes bibliográficos
Main Authors: Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, Yanting Shen, Yi Sun, Lingfan Xu, Nan Song, Yue Wang, Ming Zhan, Xu Gao, Zhong Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Molecular Metabolism
Assuntos:
Neuroendocrine prostate cancer
Castration-resistant prostate cancer
Mitochondrial pyruvate carrier
Metabolic reprogramming
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2212877822000357
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