Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)

Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted therapies in cancers has led to the development of highly aggressive carcinoma, including neuroendocrine prostate cancer (NEPC). Although metabolic repr...

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Главные авторы: Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, Yanting Shen, Yi Sun, Lingfan Xu, Nan Song, Yue Wang, Ming Zhan, Xu Gao, Zhong Wang
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2022-05-01
Серии:Molecular Metabolism
Предметы:
Neuroendocrine prostate cancer
Castration-resistant prostate cancer
Mitochondrial pyruvate carrier
Metabolic reprogramming
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2212877822000357
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