CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells

Background/Aims: Metastasis is the major cause of death in patients with osteosarcoma. There is an urgent need to identify molecular markers that promote metastasis. Cluster of differentiation 44 is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biologic...

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Bibliographic Details
Main Authors: Tang Liu, Zuyun Yan, Yong Liu, Edwin Choy, Francis J. Hornicek, Henry Mankin, Zhenfeng Duan
Format: Artigo
Language:Inglês
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Osteosarcoma
CRISPR-Cas9
Meta-analysis
CD44
Metastases
Gene therapy
Online Access:https://www.karger.com/Article/FullText/489072
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