Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

Abstract Background Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments avail...

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Hauptverfasser: Wenhui Qu, Andrea Johnson, Joo Hyun Kim, Abigail Lukowicz, Daniel Svedberg, Marija Cvetanovic
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-05-01
Schriftenreihe:Journal of Neuroinflammation
Schlagworte:
Spinocerebellar Ataxia type 1
Neuroinflammation
Cerebellum
Motor deficit
ATAXIN-1
Microglia
Online Zugang:http://link.springer.com/article/10.1186/s12974-017-0880-z
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