Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature

Our understanding of Alzheimer’s disease (AD) pathogenesis has developed with several hypotheses over the last 40 years, including the Amyloid and Tau hypotheses. More recently, the p53 protein, well-known as a genome guardian, has gained attention for its potential role in the early evolution of AD...

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Bibliographic Details
Main Authors: James S. Clark, Rakez Kayed, Giulia Abate, Daniela Uberti, Paul Kinnon, Simona Piccirella
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
p53
Alzheimer’s disease (AD)
post translational modification (PTM)
review
TP53
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.835288/full
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