Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents

In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a–s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also...

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Detalhes bibliográficos
Main Authors: Ahmet Özdemir, Mehlika Dilek Altıntop, Zafer Asım Kaplancıklı, Özgür Devrim Can, Ümide Demir Özkay, Gülhan Turan-Zitouni
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2015-02-01
Colecção:Molecules
Assuntos:
pyrazoline
antidepressant activity
tail suspension test
modified forced swimming test
activity cage
Acesso em linha:http://www.mdpi.com/1420-3049/20/2/2668
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