DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer

Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415, a small molecule targeting TRIP13. It de...

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Hauptverfasser: Sumit Agarwal, Farrukh Afaq, Prachi Bajpai, Hyung‐Gyoon Kim, Amr Elkholy, Michael Behring, Darshan Shimoga Chandrashekar, Sameer Al Diffalha, Moh’d Khushman, Shajan P. Sugandha, Sooryanarayana Varambally, Upender Manne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2022-04-01
Schriftenreihe:Molecular Oncology
Schlagworte:
colorectal cancer
DCZ0415
FGFR4
granzyme B
metastasis
TRIP13
Online Zugang:https://doi.org/10.1002/1878-0261.13201
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