Inhibition of the Unfolded Protein Response by Ricin A-Chain Enhances Its Cytotoxicity in Mammalian Cells

Ricin is a highly toxic type II ribosome-inactivating protein that has potential as a biochemical weapon and as the toxic component of immunotoxins. The unfolded protein response (UPR) is a survival response that helps cells to recover from endoplasmic reticulum (ER) stress. Failure to recover from...

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Main Authors: Wendie S. Cohick, Amanda E. Jetzt, Ju-Shun Cheng, Chao-Ting Wang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2011-05-01
Series:Toxins
Assuntos:
ricin
RTA
ER stress
unfolded protein response
apoptosis
caspase
X-box binding protein1 splicing
IRE1 phosphorylation
eIF2-α phosphorylation
epithelial cells
Acceso en liña:http://www.mdpi.com/2072-6651/3/5/453/
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