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Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome

Ricin is a potent ribotoxin that is considered a bioterror threat due to its ease of isolation and possibility of aerosolization. In yeast, mutation of arginine residues away from the active site results in a ricin toxin A chain (RTA) variant that is unable to bind the ribosome and exhibits reduced...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Jetzt, Amanda E., Li, Xiao-Ping, Tumer, Nilgun E., Cohick, Wendie S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079286/
https://ncbi.nlm.nih.gov/pubmed/27639428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.09.004
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