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Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome
Ricin is a potent ribotoxin that is considered a bioterror threat due to its ease of isolation and possibility of aerosolization. In yeast, mutation of arginine residues away from the active site results in a ricin toxin A chain (RTA) variant that is unable to bind the ribosome and exhibits reduced...
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| Publicado en: | Toxicol Appl Pharmacol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079286/ https://ncbi.nlm.nih.gov/pubmed/27639428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.09.004 |
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