TLR4 Signaling and Heme Oxygenase-1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment

Relapse in multiple myeloma (MM) decreases therapy efficiency through unclear mechanisms of chemoresistance. Since our group previously demonstrated that heme oxygenase-1 (HO-1) and Toll-like receptor 4 (TLR4) are two signaling pathways protecting MM cells from the proteasome inhibitor bortezomib (B...

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Auteurs principaux: Grazia Scandura, Cesarina Giallongo, Fabrizio Puglisi, Alessandra Romano, Nunziatina Laura Parrinello, Tatiana Zuppelli, Lucia Longhitano, Sebastiano Giallongo, Michelino Di Rosa, Giuseppe Musumeci, Roberto Motterlini, Roberta Foresti, Giuseppe Alberto Palumbo, Giovanni Li Volti, Francesco Di Raimondo, Daniele Tibullo
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2022-04-01
Collection:Antioxidants
Sujets:
multiple myeloma
TLR4/HO-1 crosstalk
mitochondria
bortezomib
Accès en ligne:https://www.mdpi.com/2076-3921/11/4/767
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